Curcumin as a anxiety and rest administration nutritional supplement

Turmeric—or much more exclusively its most important bioactive compound, curcumin—is just one of the most well-known nutraceuticals in use right now. In simple fact, a report1 by Grand View Investigate predicted that the world wide curcumin current market will achieve $94.3 million by 2022. This is dependable with a extra current report from World wide Market place Insights2, whose details predicts the world curcumin market will exceed $145 million by 2027.

Why is curcumin so well known? Like vitamin D, curcumin is just one of those people nutraceuticals for which study indicates a broad vary of opportunity advantages. Also, turmeric has been made use of as a regular treatment in Chinese and Indian Ayurvedic medicine for about 2,000 many years3, and the authors of a textbook on bioactive meals indicate that “the use of turmeric in Indian people drugs is just one of a veritable panacea, seemingly efficacious for disorders that we would today classify in the realm of infectious, inflammatory, metabolic, and immunological ailments.”4

Just one of curcumin’s lesser-recognized gains is its outcomes on pressure/stress and slumber.


How can curcumin support deal with tension/anxiousness and snooze? The reply is serotonin. Serotonin is a neurotransmitter that stabilizes our mood, inner thoughts of very well-being, and joy. This neurotransmitter also assists with sleeping, eating, and digestion.

As it turns out, in animal research, curcumin supplementation was located to increase serotonin concentrations.5 In just one analyze6, chronically stressed rats were being supplemented with curcumin. Curcumin substantially prevented the tension-induced lower in serotonin, supporting to overcome stress-induced behavioral abnormalities. In another rat research, curcumin supplementation helped restore serotonin harmony when liquor usage experienced adversely afflicted it.7


Persistent exposure to worry is a well-known threat variable for the improvement of temper and anxiety problems. Scientists analyzed8 the efficacy of curcumin in advertising resilience to serious social pressure in mice. The curcumin administration created a 4.5-fold maximize in strain resilience in the bulk of mice. These mice also produced less corticosterone (a tension hormone) following acute restraint strain, and experienced reduce amounts of peripheral IL-6 (an inflammatory compound). Curcumin also prevented anxiety-like conduct.

The consequences of curcumin (1 g/day) or placebo have been also tested on the frequency of signs and symptoms of nervousness and despair in 30 overweight human subjects in a 30-working day, double-blind, crossover trial.9 Severity of anxiousness and despair was assessed at baseline and at weeks 4, 6, and 10 of the demo utilizing the Beck Stress Inventory and Beck Despair Stock, both equally scientifically validated assessment questionnaires. Effects confirmed that anxiousness scores ended up drastically minimized adhering to curcumin remedy (P=.03).

Equivalent results ended up viewed in other investigation, including scientific studies on:

  • 80 mg of nano-curcumin exhibiting performance in minimizing depression and stress scores in clients with diabetic polyneuropathy10
  • 500-1000 mg of curcumin and blended curcumin/saffron showing success in decreasing depression and stress indications in people today with key depressive disorder11
  • 1 g of curcumin showing anti-anxiousness effect in people with obesity12
  • 1000 mg of curcumin in addition 10 mg of piperine demonstrating appreciably better lowered panic and despair signs or symptoms as an increase-on to common medication in sufferers with significant depressive condition13


A randomized, double-blind, placebo-managed demo14 was performed to determine the effects of 1000 mg/working day curcumin or placebo on high quality of existence (QoL) in 58 sufferers aged 20-70 decades with liver cirrhosis. As opposed with baseline, in general QoL scores enhanced noticeably (P < 0.05) after curcumin administration. Furthermore, curcumin helped significantly reduce (P < 0.05) the following: sleeping during the day, decreased sexual interest, and decreased sexual activity.

Another study15 was conducted to examine the effect of turmeric supplementation on quality of life (QoL) and hematological parameters in 60 breast cancer patients on chemotherapy. Turmeric supplementation for 21 days resulted in clinically relevant and statistically significant improvement in global health status symptom scores, including fatigue and insomnia.


Although known mostly for its anti-inflammatory effects, curcumin clearly has value for positively impacting stress/anxiety and sleep due at least in part to its ability to increase serotonin levels.

Gene Bruno, MS, MHS, RH (AHG) possesses 42 years of dietary supplement industry experience. With a master’s degree in nutrition and a second master’s degree in herbal medicine, he has a proven track record of formulating innovative, evidence-based dietary supplements. Bruno currently serves as both the vice president of scientific and regulatory affairs at NutraScience Labs (Farmingdale, NY) and professor of nutraceutical science at Huntington University of Health Sciences (Knoxville, TN).


  1. PR Newswire press release. “Curcumin Market Is Anticipated to Grow to $94.3 Million By 2022: Grand View Research, Inc.” Published June 22, 2015.
  2. Global Market Insights report. “Curcumin Market Size to Exceed $145 Mn by 2027.” Published July 14, 2021.
  3. Curcuma longa (turmeric). Monograph.” Alternative Medicine Review, supplement 6 (September 2001): S62-S66
  4. Togni S, Appendino G. “Curcumin and Joint Health: From Traditional Knowledge to Clinical Validation.” Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases edited by Watson RR, Preedy VR Academic Press 2013: 67-81
  5. Kulkarni SK et al. “Antidepressant activity of curcumin: Involvement of serotonin and dopamine system.” Psychopharmacology (Berl), vol. 201, no. 3 (December 2008): 435-342
  6. Xu Y et al. “Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats.” Brain Research. Published online June 21, 2007.
  7. Jagota A et al. “The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal.” Cellular and Molecular Neurobiology, vol. 27, no. 8 (December 2007): 997-1006
  8. Aubry AV et al. “A diet enriched with curcumin promotes resilience to chronic social defeat stress.” Neuropsychopharmacology, vol. 44, no. 4 (March 2019):733-742
  9. Esmaily H et al. “An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial.” Chinese Journal of Integrative Medicine. Published online March 17, 2015.
  10. Asadi S et al. “Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial.” Phytotherapy Research, vol. 34, no. 4 (April 2020): 896-903
  11. Lopresti AL et al. “Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study.Journal of Affective Disorders, vol. 207 (January 1, 2017): 188-196
  12. Esmaily H et al. “An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial.Chinese Journal of Integrative Medicine, vol. 21, no. 5 (May 2015): 332-338
  13. Panahi Y et al. “Investigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive disorder.Phytotherapy Research, vol. 29, no. 1 (January 2015): 17-21
  14. Nouri-Vaskeh M et al. “Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: A randomized, double-blind placebo-controlled trial.Complementary Therapies in Medicine. Published online February 19, 2020.
  15. Kalluru H et al. “Turmeric supplementation improves the quality of life and hematological parameters in breast cancer patients on paclitaxel chemotherapy: A case series.” Complementary Therapies in Clinical Practice. Published online October 13, 2020.